Publications

Google Scholar
NCBI

2022

Engineered implantable vaccine platform for continuous antigen-specific immunomodulation

Viswanath DI, Liu HC, Capuani S, Vander Pol RS, Saunders SZ, Chua CYX, Grattoni A.
Biomaterials. 2022 Feb; 281:121374.

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines

Viswanath DI, Liu HC, Huston DP, Chua CYX, Grattoni A.
Biomaterials. 2022 Jan; 280:121297.

2021

Emerging strategies for beta cell transplantation to treat diabetes

Paez-Mayorga, J., Lukin, I., Emerich, D., de Vos, P., Orive, G., and Grattoni, A. (2021)
Trends in Pharmacological Sciences

Tenofovir Alafenamide (TAF) for HIV Prevention: Review of the Proceedings from the Gates Foundation Long Acting (LA) TAF Product Development Meeting

Romano, J.W., Baum, M., Demkovich, Z.R., Diana, F., Dobard, C., Feldman, P.L., Garcia-Lerma, J.G., Grattoni, A., Gunawardana, M., Ho, Duy-Khiet, Hope, T.J., Massud, I., Milad, M., Moss, J., Pons-Faudoa, F.P., Roller, S., van der Straten, A., Srinivasan, S., Veazey, R., Zane, D.
AIDS Research and Human Retroviruses, 37:6, 2021, pp. 409-420

Extending Drug Release from Implants via Transcutaneous Refilling with Solid Therapeutics

Di Trani, N.; Pons-Faudoa, F. P.; Sizovs, A.; Shelton, K. A.; Marzinke, M. A.; Nehete, P. N.; Grattoni, A
Advanced Therapeutics 2022, 2100214

Silicon carbide gated nanofluidic membrane for active control of electrokinetic ionic transport

Silvestri A., Di Trani N., Canavese G., Motto Ros P., Iannucci L., Grassini S., Wang Y., Liu X., Demarchi D., Grattoni A.
Membranes 2021,11,535.

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension

Di Trani N., Liu H.C., Qi R., Viswanath I. D., Liu X., Chua C.Y.X., Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine 37 (2021): 102417.

Carbon fiber reinforced polymers for implantable medical devices

Chua, C.Y.X., Liu, H.C., Di Trani, N., Susnjar, A., Ho, J., Scorrano, G., Rhudy, J., Sizovs, A., Lolli, G., Hernandez, N. and Nucci, M.C.
Biomaterials, 2021, p.120719.

2020

Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem Cells

Paez‐Mayorga, J., Capuani, S., Farina, M., Lotito, M. L., Niles, J. A., Salazar, H. F., Rhudy, J., Esnaola, L., Chua, C.Y.X., Taraballi, F., Corradetti B., Shelton, K.A., Nehete, P.N., Nichols, J.E. and Grattoni, A.
Advanced Healthcare Materials, 2020, 9(19), 2000670.

Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applications

Sizovs, A., Pons-Faudoa, F.P., Malgir, G., Shelton, K.A., Bushman, L.R., Chua, C.Y.X., Anderson, P.L., Nehete, P.N., Sastry, K.J., Grattoni, A.
International Journal of Pharmaceutics, 587, 2020

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates

Pons-Faudoa, F.P., Sizovs, A., Shelton, K.A., Momin, Z., Niles, J.A., Bushman, L.R., Xu, J., Chua, C.Y.X., Nichols, J.E., Demaria, S., Ittmann, M.M., Hawkins, T., Rooney, J.F., Marzinke, M.A., Kimata, J.T., Anderson, P.L., Nehete, P.N., Arduino, R.C., Ferrari, M., Sastry, K.J., Grattoni, A.
Advanced Therapeutics, 2020, 4(3), 2000163

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation

Paez-Mayorga, J., Capuani, S., Hernandez, N., Farina, M., Chua, C. Y. X., Blanchard, R., Sizovs, A., Liu, H.C., Fraga, D.W., Niles, J.A., Salazar, H.F., Corradetti, B., Sikora, A.G., Kloc, M., Li, X.C., Gaber, A.O., Nichols, J.E. and Grattoni, A
Biomaterials2020, 257, 120232.

Viral load Reduction in SHIV-Positive Nonhuman Primates via Long-Acting Subcutaneous Tenofovir Alafenamide Fumarate Release from a Nanofluidic Implant

Pons-Faudoa, F. P.; Di Trani, N.; Sizovs, A.; Shelton, K. A.; Momin, Z.; Bushman, L. R.; Xu, J.; Lewis, D. E.; Demaria, S.; Hawkins, T.; Rooney, J. F.; Marzinke, M. A.; Kimata, J. T.; Anderson, P. L.; Nehete, P. N.; Arduino, R. C.; Sastry, K. J.; Grattoni, A.
Pharmaceutics 2020, 12 (10), 981.

Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and antiPDL1

Liu, H.C., Viswanath, D.I., Pesaresi, F., Xu, Y., Zhang, L., Di Trani, N., Paez-Mayorga, J., Hernandez, N., Wang, Y., Erm, D.R. and Ho, J.,
International Journal of Radiation Oncology Biology Physics 2020

Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution

Di Trani, N.; Silvestri, A.; Wang, Y.; Demarchi, D.; Liu, X.; Grattoni, A.
Pharmaceutics 2020, 12, 679.

Intratumoral nanofluidic system for enhancing tumor biodistribution of agonist CD40 antibody

Chua C. Y. X., Ho J., Susnjar A., Lolli G., Di Trani N., Pesaresi F., Sizovs A., Zhang M., Nance E., and Grattoni A.
Advanced Therapeutics, 2020, 2000055.

Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol

Ballerini A., Chua C. Y. X., Rhudy J., A. Susnjar, Di Trani N., Jain P. R., Laue g., Lubicka D., Shirazi‐Fard Y., Ferrari M., Stodieck L. S., Cadena S. M. and Grattoni A.
Advanced Therapeutics, 3(7), 2000014.

Electrostatically Gated Nanofluidic Membrane for Ultra-Low Power Controlled Drug Delivery

Di Trani N., Silvestri A., Sizovs A., Wang Y., Erm D. R., Demarchi D., Liu X. and Grattoni A.
Lab on a Chip, 2020, 20, 1562–1576

Finite-Size Charged Species Diffusion and pH Change in Nanochannels

Di Trani, N., Pimpinelli, A. & Grattoni, A.
ACS Applied Materials & Interfaces 2020, 12, 12246-12255

2019

2-Hydroxypropyl-β-Cyclodextrin-Enhanced Pharmacokinetics of Cabotegravir from a Nanofluidic Implant for HIV Pre-Exposure Prophylaxis

Pons-Faudoa, F. P.; Sizovs, A.; Di Trani, N.; Paez-Mayorga, J.; Bruno, G.; Rhudy, J.; Manohar, M.; Gwenden, K.; Martini, C.; Chua, C. Y. X.; Varchi, G.; Marzinke, M. A.; Grattoni, A.
Journal of Controlled Release 2019, 306, 89–96.

Remotely Controlled Nanofluidic Implantable Platform for Tunable Drug Delivery

Di Trani, N.; Silvestri, A.; Bruno, G.; Geninatti, T.; Chua, C. Y. X.; Gilbert, A.; Rizzo, G.; Filgueira, C. S.; Demarchi, D.; Grattoni, A.
Lab on a Chip 2019, 19 (13), 2192–2204.

Nanofluidic microsystem for sustained intraocular delivery of therapeutics

Di Trani N, Jain P, Bruno G, Chua CYX., Ho JS, Hood LR, Smith ZW, Ballerini A, Filgueira CS, Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine. 2019 Feb 1;16:1–9.

2018

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis

Chua CY, Jain P, Ballerini A, Bruno G, Hood RL, Gupte M, Gao S, Di Trani N, Susnjar A, Shelton K, Bushman LR. Folci M., Filgueira CS, Marzinke M A, Anderson PL, Hu M, Nehete P, Arduino RC, Sastry JK, Grattoni A
Journal of Controlled Release. 2018 Sep 28;286:315-25.

Gas Flow at the Ultra-nanoscale: Universal Predictive Model and Validation in Nanochannels of Ångstrom-Level Resolution

Scorrano G, Bruno G, Di Trani N, Ferrari M, Pimpinelli A, Grattoni A.
ACS Applied Materials & Interfaces. 2018 Sep 5;10(38):32233-8

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale

Bruno G, Di Trani N, Hood R, Zabre E, Filgueira C, Canavese G, Jain P, Smith Z, Demarchi D, Hosali S, Pimpinelli A, Ferrari M, Grattoni A.
Nature Communications, 2018 Apr 27;9(1):1682.

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer

Chua, C. Y. X.; Jain, P.; Susnjar, A.; Rhudy, J.; Folci, M.; Ballerini, A.; Gilbert, A.; Singh, S.; Bruno, G.; Filgueira, C. S.
Journal of Controlled Release 2018, 285, 23-34

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells

Farina, M.; Chua, C. Y. X.; Ballerini, A.; Thekkedath, U.; Alexander, J. F.; Rhudy, J. R.; Torchio, G.; Fraga, D.; Pathak, R. R.; Villanueva, M.
Biomaterials 2018, 177, 125-138

Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

Farina, M.; Alexander, J. F.; Thekkedath, U.; Ferrari, M.; Grattoni, A.
Advanced Drug Delivery Reviews 2019, 139, 92-115
Full list on Google Scholar

2022

Engineered implantable vaccine platform for continuous antigen-specific immunomodulation

Viswanath DI, Liu HC, Capuani S, Vander Pol RS, Saunders SZ, Chua CYX, Grattoni A.
Biomaterials. 2022 Feb; 281:121374.

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines

Viswanath DI, Liu HC, Huston DP, Chua CYX, Grattoni A.
Biomaterials. 2022 Jan; 280:121297.

2021

Emerging strategies for beta cell transplantation to treat diabetes

Paez-Mayorga, J., Lukin, I., Emerich, D., de Vos, P., Orive, G., and Grattoni, A. (2021)
Trends in Pharmacological Sciences

Tenofovir Alafenamide (TAF) for HIV Prevention: Review of the Proceedings from the Gates Foundation Long Acting (LA) TAF Product Development Meeting

Romano, J.W., Baum, M., Demkovich, Z.R., Diana, F., Dobard, C., Feldman, P.L., Garcia-Lerma, J.G., Grattoni, A., Gunawardana, M., Ho, Duy-Khiet, Hope, T.J., Massud, I., Milad, M., Moss, J., Pons-Faudoa, F.P., Roller, S., van der Straten, A., Srinivasan, S., Veazey, R., Zane, D.
AIDS Research and Human Retroviruses, 37:6, 2021, pp. 409-420

Extending Drug Release from Implants via Transcutaneous Refilling with Solid Therapeutics

Di Trani, N.; Pons-Faudoa, F. P.; Sizovs, A.; Shelton, K. A.; Marzinke, M. A.; Nehete, P. N.; Grattoni, A
Advanced Therapeutics 2022, 2100214

Silicon carbide gated nanofluidic membrane for active control of electrokinetic ionic transport

Silvestri A., Di Trani N., Canavese G., Motto Ros P., Iannucci L., Grassini S., Wang Y., Liu X., Demarchi D., Grattoni A.
Membranes 2021,11,535.

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension

Di Trani N., Liu H.C., Qi R., Viswanath I. D., Liu X., Chua C.Y.X., Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine 37 (2021): 102417.

Carbon fiber reinforced polymers for implantable medical devices

Chua, C.Y.X., Liu, H.C., Di Trani, N., Susnjar, A., Ho, J., Scorrano, G., Rhudy, J., Sizovs, A., Lolli, G., Hernandez, N. and Nucci, M.C.
Biomaterials, 2021, p.120719.

2020

Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem Cells

Paez‐Mayorga, J., Capuani, S., Farina, M., Lotito, M. L., Niles, J. A., Salazar, H. F., Rhudy, J., Esnaola, L., Chua, C.Y.X., Taraballi, F., Corradetti B., Shelton, K.A., Nehete, P.N., Nichols, J.E. and Grattoni, A.
Advanced Healthcare Materials, 2020, 9(19), 2000670.

Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applications

Sizovs, A., Pons-Faudoa, F.P., Malgir, G., Shelton, K.A., Bushman, L.R., Chua, C.Y.X., Anderson, P.L., Nehete, P.N., Sastry, K.J., Grattoni, A.
International Journal of Pharmaceutics, 587, 2020

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates

Pons-Faudoa, F.P., Sizovs, A., Shelton, K.A., Momin, Z., Niles, J.A., Bushman, L.R., Xu, J., Chua, C.Y.X., Nichols, J.E., Demaria, S., Ittmann, M.M., Hawkins, T., Rooney, J.F., Marzinke, M.A., Kimata, J.T., Anderson, P.L., Nehete, P.N., Arduino, R.C., Ferrari, M., Sastry, K.J., Grattoni, A.
Advanced Therapeutics, 2020, 4(3), 2000163

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation

Paez-Mayorga, J., Capuani, S., Hernandez, N., Farina, M., Chua, C. Y. X., Blanchard, R., Sizovs, A., Liu, H.C., Fraga, D.W., Niles, J.A., Salazar, H.F., Corradetti, B., Sikora, A.G., Kloc, M., Li, X.C., Gaber, A.O., Nichols, J.E. and Grattoni, A
Biomaterials2020, 257, 120232.

Viral load Reduction in SHIV-Positive Nonhuman Primates via Long-Acting Subcutaneous Tenofovir Alafenamide Fumarate Release from a Nanofluidic Implant

Pons-Faudoa, F. P.; Di Trani, N.; Sizovs, A.; Shelton, K. A.; Momin, Z.; Bushman, L. R.; Xu, J.; Lewis, D. E.; Demaria, S.; Hawkins, T.; Rooney, J. F.; Marzinke, M. A.; Kimata, J. T.; Anderson, P. L.; Nehete, P. N.; Arduino, R. C.; Sastry, K. J.; Grattoni, A.
Pharmaceutics 2020, 12 (10), 981.

Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and antiPDL1

Liu, H.C., Viswanath, D.I., Pesaresi, F., Xu, Y., Zhang, L., Di Trani, N., Paez-Mayorga, J., Hernandez, N., Wang, Y., Erm, D.R. and Ho, J.,
International Journal of Radiation Oncology Biology Physics 2020

Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution

Di Trani, N.; Silvestri, A.; Wang, Y.; Demarchi, D.; Liu, X.; Grattoni, A.
Pharmaceutics 2020, 12, 679.

Intratumoral nanofluidic system for enhancing tumor biodistribution of agonist CD40 antibody

Chua C. Y. X., Ho J., Susnjar A., Lolli G., Di Trani N., Pesaresi F., Sizovs A., Zhang M., Nance E., and Grattoni A.
Advanced Therapeutics, 2020, 2000055.

Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol

Ballerini A., Chua C. Y. X., Rhudy J., A. Susnjar, Di Trani N., Jain P. R., Laue g., Lubicka D., Shirazi‐Fard Y., Ferrari M., Stodieck L. S., Cadena S. M. and Grattoni A.
Advanced Therapeutics, 3(7), 2000014.

Electrostatically Gated Nanofluidic Membrane for Ultra-Low Power Controlled Drug Delivery

Di Trani N., Silvestri A., Sizovs A., Wang Y., Erm D. R., Demarchi D., Liu X. and Grattoni A.
Lab on a Chip, 2020, 20, 1562–1576

Finite-Size Charged Species Diffusion and pH Change in Nanochannels

Di Trani, N., Pimpinelli, A. & Grattoni, A.
ACS Applied Materials & Interfaces 2020, 12, 12246-12255

2019

2-Hydroxypropyl-β-Cyclodextrin-Enhanced Pharmacokinetics of Cabotegravir from a Nanofluidic Implant for HIV Pre-Exposure Prophylaxis

Pons-Faudoa, F. P.; Sizovs, A.; Di Trani, N.; Paez-Mayorga, J.; Bruno, G.; Rhudy, J.; Manohar, M.; Gwenden, K.; Martini, C.; Chua, C. Y. X.; Varchi, G.; Marzinke, M. A.; Grattoni, A.
Journal of Controlled Release 2019, 306, 89–96.

Remotely Controlled Nanofluidic Implantable Platform for Tunable Drug Delivery

Di Trani, N.; Silvestri, A.; Bruno, G.; Geninatti, T.; Chua, C. Y. X.; Gilbert, A.; Rizzo, G.; Filgueira, C. S.; Demarchi, D.; Grattoni, A.
Lab on a Chip 2019, 19 (13), 2192–2204.

Nanofluidic microsystem for sustained intraocular delivery of therapeutics

Di Trani N, Jain P, Bruno G, Chua CYX., Ho JS, Hood LR, Smith ZW, Ballerini A, Filgueira CS, Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine. 2019 Feb 1;16:1–9.

2018

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis

Chua CY, Jain P, Ballerini A, Bruno G, Hood RL, Gupte M, Gao S, Di Trani N, Susnjar A, Shelton K, Bushman LR. Folci M., Filgueira CS, Marzinke M A, Anderson PL, Hu M, Nehete P, Arduino RC, Sastry JK, Grattoni A
Journal of Controlled Release. 2018 Sep 28;286:315-25.

Gas Flow at the Ultra-nanoscale: Universal Predictive Model and Validation in Nanochannels of Ångstrom-Level Resolution

Scorrano G, Bruno G, Di Trani N, Ferrari M, Pimpinelli A, Grattoni A.
ACS Applied Materials & Interfaces. 2018 Sep 5;10(38):32233-8

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale

Bruno G, Di Trani N, Hood R, Zabre E, Filgueira C, Canavese G, Jain P, Smith Z, Demarchi D, Hosali S, Pimpinelli A, Ferrari M, Grattoni A.
Nature Communications, 2018 Apr 27;9(1):1682.

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer

Chua, C. Y. X.; Jain, P.; Susnjar, A.; Rhudy, J.; Folci, M.; Ballerini, A.; Gilbert, A.; Singh, S.; Bruno, G.; Filgueira, C. S.
Journal of Controlled Release 2018, 285, 23-34

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells

Farina, M.; Chua, C. Y. X.; Ballerini, A.; Thekkedath, U.; Alexander, J. F.; Rhudy, J. R.; Torchio, G.; Fraga, D.; Pathak, R. R.; Villanueva, M.
Biomaterials 2018, 177, 125-138

Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

Farina, M.; Alexander, J. F.; Thekkedath, U.; Ferrari, M.; Grattoni, A.
Advanced Drug Delivery Reviews 2019, 139, 92-115
Full list on Google Scholar

Patents

2020 U.S. Provisional Pat. Ser. No. 63/043,439. “Transcutaneously refillable cell confinement platform with local trophic factor delivery.” Grattoni, A., Paez-Mayorga, J. & Capuani, S.

2020 US Provisional Patent Application 62,961,294, “Formulations for stabilizing phosphonamidite esters in long-term drug delivery systems.” Grattoni A., Sizovs A., Pons F.P.

2020 US Provisional Patent Application 62/943,993, “Methods for loading drug-delivery implants with solid materials.” Grattoni A., Sizovs  A.

2020 US Provisional Patent Application 62/961,437, “Gated nanofluidic valve for active and passive electrosteric control of molecular transport, and methods of fabrication.” Grattoni A., Liu, X., Ferrari, M.

2017 US Patent Application 62/573,339, “Delivery Devices.” Farina M., Ballerini A., Gaber A.O., Grattoni, A.

2015 US Provisional Patent Application No. 62/161,986, Mechanism to remotely and externally cease drug delivery in vivo.” Grattoni A., Farina M., Hood, RL.

2015 US Provisional Patent Application No. 61/861,070. “Nanochanneled Device with Electrodes and Related Methods.” Fine D., Grattoni A., Hussain F., Ferrari M., Liu X., Goodall R., Hosali S.

2014 US Provisional Patent Application No. 62/161,986, “Implantable Nanochannel Drug (e.g., chemotherapy, antobodies gene therapy in viral particles) Delivery Combined with Fiducial Markers and Radioactive Seeds for Sustained, Multi-modal Cancer Treatment.” Grattoni A., Palapattu G., Butler BE.

2014 US Patent Application No. US 13/698,926, “Nanochanneled Device and Related Methods.” Grattoni A., Mann A., Hosali S., Goodall R., Hudson L.

2014 US Patent No. 8,632,510, “Nanochanneled Device and Related Methods.” Mauro Ferrari, Xuewu Liu, Grattoni A., Goodall R., Hudson L. (also pending in Canada, China, Europe).

2013 US Patent Application No. PCT/US2013/022987. “Sustained drug delivery from solid implants with nanochannel membranes.” Grattoni A., Palapattu G., Khera M.

2013 US Patent No. 8,480,637, “Nanochanneled Device and Related Methods.” Mauro Ferrari, Xuewu Liu, Grattoni A., Goodall R., Hudson L. (also pending in Canada, China, Europe).

2009 US Patent Application No. 13/659,064, “Device and Method for Sustained Release of Therapeutic Agent.” Grattoni A., De Rosa E., Goodall R., Hudson L., Crowley M. (also International Patent Application No. PCT/US2012/061536).

2007 US Patent Application No. PCT/US2009/041957 “Quality control method and micro/nano-channeled devices.” Grattoni A., Ferrari M., Liu X.

2006 IT Patent No. TO2007A000177. “Dispositivo perfezionato di misura della pressione osmotica e relative procedimento di misura.” Canavese G., Grattoni A.

2006 IT Patent No. T02006A000508. “Osmotic pressure measurement device and measurement method.” Grattoni A., Canavese G.