2024
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2023
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2022
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Engineered implantable vaccine platform for continuous antigen-specific immunomodulationViswanath DI, Liu HC, Capuani S, Vander Pol RS, Saunders SZ, Chua CYX, Grattoni A.
Biomaterials. 2022 Feb; 281:121374.
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Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccinesViswanath DI, Liu HC, Huston DP, Chua CYX, Grattoni A.
Biomaterials. 2022 Jan; 280:121297.
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2021
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Emerging strategies for beta cell transplantation to treat diabetesPaez-Mayorga, J., Lukin, I., Emerich, D., de Vos, P., Orive, G., and Grattoni, A. (2021)
Trends in Pharmacological Sciences
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Tenofovir Alafenamide (TAF) for HIV Prevention: Review of the Proceedings from the Gates Foundation Long Acting (LA) TAF Product Development MeetingRomano, J.W., Baum, M., Demkovich, Z.R., Diana, F., Dobard, C., Feldman, P.L., Garcia-Lerma, J.G., Grattoni, A., Gunawardana, M., Ho, Duy-Khiet, Hope, T.J., Massud, I., Milad, M., Moss, J., Pons-Faudoa, F.P., Roller, S., van der Straten, A., Srinivasan, S., Veazey, R., Zane, D.
AIDS Research and Human Retroviruses, 37:6, 2021, pp. 409-420
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Extending Drug Release from Implants via Transcutaneous Refilling with Solid TherapeuticsDi Trani, N.; Pons-Faudoa, F. P.; Sizovs, A.; Shelton, K. A.; Marzinke, M. A.; Nehete, P. N.; Grattoni, A
Advanced Therapeutics 2022, 2100214
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Silicon carbide gated nanofluidic membrane for active control of electrokinetic ionic transportSilvestri A., Di Trani N., Canavese G., Motto Ros P., Iannucci L., Grassini S., Wang Y., Liu X., Demarchi D., Grattoni A.
Membranes 2021,11,535.
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Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertensionDi Trani N., Liu H.C., Qi R., Viswanath I. D., Liu X., Chua C.Y.X., Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine 37 (2021): 102417.
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Carbon fiber reinforced polymers for implantable medical devicesChua, C.Y.X., Liu, H.C., Di Trani, N., Susnjar, A., Ho, J., Scorrano, G., Rhudy, J., Sizovs, A., Lolli, G., Hernandez, N. and Nucci, M.C.
Biomaterials, 2021, p.120719.
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2020
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Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem CellsPaez‐Mayorga, J., Capuani, S., Farina, M., Lotito, M. L., Niles, J. A., Salazar, H. F., Rhudy, J., Esnaola, L., Chua, C.Y.X., Taraballi, F., Corradetti B., Shelton, K.A., Nehete, P.N., Nichols, J.E. and Grattoni, A.
Advanced Healthcare Materials, 2020, 9(19), 2000670.
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Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applicationsSizovs, A., Pons-Faudoa, F.P., Malgir, G., Shelton, K.A., Bushman, L.R., Chua, C.Y.X., Anderson, P.L., Nehete, P.N., Sastry, K.J., Grattoni, A.
International Journal of Pharmaceutics, 587, 2020
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Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primatesPons-Faudoa, F.P., Sizovs, A., Shelton, K.A., Momin, Z., Niles, J.A., Bushman, L.R., Xu, J., Chua, C.Y.X., Nichols, J.E., Demaria, S., Ittmann, M.M., Hawkins, T., Rooney, J.F., Marzinke, M.A., Kimata, J.T., Anderson, P.L., Nehete, P.N., Arduino, R.C., Ferrari, M., Sastry, K.J., Grattoni, A.
Advanced Therapeutics, 2020, 4(3), 2000163
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Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantationPaez-Mayorga, J., Capuani, S., Hernandez, N., Farina, M., Chua, C. Y. X., Blanchard, R., Sizovs, A., Liu, H.C., Fraga, D.W., Niles, J.A., Salazar, H.F., Corradetti, B., Sikora, A.G., Kloc, M., Li, X.C., Gaber, A.O., Nichols, J.E. and Grattoni, A
Biomaterials, 2020, 257, 120232.
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Viral load Reduction in SHIV-Positive Nonhuman Primates via Long-Acting Subcutaneous Tenofovir Alafenamide Fumarate Release from a Nanofluidic ImplantPons-Faudoa, F. P.; Di Trani, N.; Sizovs, A.; Shelton, K. A.; Momin, Z.; Bushman, L. R.; Xu, J.; Lewis, D. E.; Demaria, S.; Hawkins, T.; Rooney, J. F.; Marzinke, M. A.; Kimata, J. T.; Anderson, P. L.; Nehete, P. N.; Arduino, R. C.; Sastry, K. J.; Grattoni, A.
Pharmaceutics 2020, 12 (10), 981.
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Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and antiPDL1Liu, H.C., Viswanath, D.I., Pesaresi, F., Xu, Y., Zhang, L., Di Trani, N., Paez-Mayorga, J., Hernandez, N., Wang, Y., Erm, D.R. and Ho, J.,
International Journal of Radiation Oncology Biology Physics 2020
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Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes ElutionDi Trani, N.; Silvestri, A.; Wang, Y.; Demarchi, D.; Liu, X.; Grattoni, A.
Pharmaceutics 2020, 12, 679.
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Intratumoral nanofluidic system for enhancing tumor biodistribution of agonist CD40 antibodyChua C. Y. X., Ho J., Susnjar A., Lolli G., Di Trani N., Pesaresi F., Sizovs A., Zhang M., Nance E., and Grattoni A.
Advanced Therapeutics, 2020, 2000055.
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Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of FormoterolBallerini A., Chua C. Y. X., Rhudy J., A. Susnjar, Di Trani N., Jain P. R., Laue g., Lubicka D., Shirazi‐Fard Y., Ferrari M., Stodieck L. S., Cadena S. M. and Grattoni A.
Advanced Therapeutics, 3(7), 2000014.
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Electrostatically Gated Nanofluidic Membrane for Ultra-Low Power Controlled Drug DeliveryDi Trani N., Silvestri A., Sizovs A., Wang Y., Erm D. R., Demarchi D., Liu X. and Grattoni A.
Lab on a Chip, 2020, 20, 1562–1576
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Finite-Size Charged Species Diffusion and pH Change in NanochannelsDi Trani, N., Pimpinelli, A. & Grattoni, A.
ACS Applied Materials & Interfaces 2020, 12, 12246-12255
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2019
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2-Hydroxypropyl-β-Cyclodextrin-Enhanced Pharmacokinetics of Cabotegravir from a Nanofluidic Implant for HIV Pre-Exposure ProphylaxisPons-Faudoa, F. P.; Sizovs, A.; Di Trani, N.; Paez-Mayorga, J.; Bruno, G.; Rhudy, J.; Manohar, M.; Gwenden, K.; Martini, C.; Chua, C. Y. X.; Varchi, G.; Marzinke, M. A.; Grattoni, A.
Journal of Controlled Release 2019, 306, 89–96.
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Remotely Controlled Nanofluidic Implantable Platform for Tunable Drug DeliveryDi Trani, N.; Silvestri, A.; Bruno, G.; Geninatti, T.; Chua, C. Y. X.; Gilbert, A.; Rizzo, G.; Filgueira, C. S.; Demarchi, D.; Grattoni, A.
Lab on a Chip 2019, 19 (13), 2192–2204.
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Nanofluidic microsystem for sustained intraocular delivery of therapeuticsDi Trani N, Jain P, Bruno G, Chua CYX., Ho JS, Hood LR, Smith ZW, Ballerini A, Filgueira CS, Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine. 2019 Feb 1;16:1–9.
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2018
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Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxisChua CY, Jain P, Ballerini A, Bruno G, Hood RL, Gupte M, Gao S, Di Trani N, Susnjar A, Shelton K, Bushman LR. Folci M., Filgueira CS, Marzinke M A, Anderson PL, Hu M, Nehete P, Arduino RC, Sastry JK, Grattoni A
Journal of Controlled Release. 2018 Sep 28;286:315-25.
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Gas Flow at the Ultra-nanoscale: Universal Predictive Model and Validation in Nanochannels of Ångstrom-Level ResolutionScorrano G, Bruno G, Di Trani N, Ferrari M, Pimpinelli A, Grattoni A.
ACS Applied Materials & Interfaces. 2018 Sep 5;10(38):32233-8
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Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscaleBruno G, Di Trani N, Hood R, Zabre E, Filgueira C, Canavese G, Jain P, Smith Z, Demarchi D, Hosali S, Pimpinelli A, Ferrari M, Grattoni A.
Nature Communications, 2018 Apr 27;9(1):1682.
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Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancerChua, C. Y. X.; Jain, P.; Susnjar, A.; Rhudy, J.; Folci, M.; Ballerini, A.; Gilbert, A.; Singh, S.; Bruno, G.; Filgueira, C. S.
Journal of Controlled Release 2018, 285, 23-34
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Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cellsFarina, M.; Chua, C. Y. X.; Ballerini, A.; Thekkedath, U.; Alexander, J. F.; Rhudy, J. R.; Torchio, G.; Fraga, D.; Pathak, R. R.; Villanueva, M.
Biomaterials 2018, 177, 125-138
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Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyondFarina, M.; Alexander, J. F.; Thekkedath, U.; Ferrari, M.; Grattoni, A.
Advanced Drug Delivery Reviews 2019, 139, 92-115
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2024
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2023
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2022
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Engineered implantable vaccine platform for continuous antigen-specific immunomodulationViswanath DI, Liu HC, Capuani S, Vander Pol RS, Saunders SZ, Chua CYX, Grattoni A.
Biomaterials. 2022 Feb; 281:121374.
|
|
Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccinesViswanath DI, Liu HC, Huston DP, Chua CYX, Grattoni A.
Biomaterials. 2022 Jan; 280:121297.
|
2021
|
Emerging strategies for beta cell transplantation to treat diabetesPaez-Mayorga, J., Lukin, I., Emerich, D., de Vos, P., Orive, G., and Grattoni, A. (2021)
Trends in Pharmacological Sciences
|
|
Tenofovir Alafenamide (TAF) for HIV Prevention: Review of the Proceedings from the Gates Foundation Long Acting (LA) TAF Product Development MeetingRomano, J.W., Baum, M., Demkovich, Z.R., Diana, F., Dobard, C., Feldman, P.L., Garcia-Lerma, J.G., Grattoni, A., Gunawardana, M., Ho, Duy-Khiet, Hope, T.J., Massud, I., Milad, M., Moss, J., Pons-Faudoa, F.P., Roller, S., van der Straten, A., Srinivasan, S., Veazey, R., Zane, D.
AIDS Research and Human Retroviruses, 37:6, 2021, pp. 409-420
|
|
Extending Drug Release from Implants via Transcutaneous Refilling with Solid TherapeuticsDi Trani, N.; Pons-Faudoa, F. P.; Sizovs, A.; Shelton, K. A.; Marzinke, M. A.; Nehete, P. N.; Grattoni, A
Advanced Therapeutics 2022, 2100214
|
|
Silicon carbide gated nanofluidic membrane for active control of electrokinetic ionic transportSilvestri A., Di Trani N., Canavese G., Motto Ros P., Iannucci L., Grassini S., Wang Y., Liu X., Demarchi D., Grattoni A.
Membranes 2021,11,535.
|
|
Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertensionDi Trani N., Liu H.C., Qi R., Viswanath I. D., Liu X., Chua C.Y.X., Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine 37 (2021): 102417.
|
|
Carbon fiber reinforced polymers for implantable medical devicesChua, C.Y.X., Liu, H.C., Di Trani, N., Susnjar, A., Ho, J., Scorrano, G., Rhudy, J., Sizovs, A., Lolli, G., Hernandez, N. and Nucci, M.C.
Biomaterials, 2021, p.120719.
|
2020
|
Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem CellsPaez‐Mayorga, J., Capuani, S., Farina, M., Lotito, M. L., Niles, J. A., Salazar, H. F., Rhudy, J., Esnaola, L., Chua, C.Y.X., Taraballi, F., Corradetti B., Shelton, K.A., Nehete, P.N., Nichols, J.E. and Grattoni, A.
Advanced Healthcare Materials, 2020, 9(19), 2000670.
|
|
Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applicationsSizovs, A., Pons-Faudoa, F.P., Malgir, G., Shelton, K.A., Bushman, L.R., Chua, C.Y.X., Anderson, P.L., Nehete, P.N., Sastry, K.J., Grattoni, A.
International Journal of Pharmaceutics, 587, 2020
|
|
Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primatesPons-Faudoa, F.P., Sizovs, A., Shelton, K.A., Momin, Z., Niles, J.A., Bushman, L.R., Xu, J., Chua, C.Y.X., Nichols, J.E., Demaria, S., Ittmann, M.M., Hawkins, T., Rooney, J.F., Marzinke, M.A., Kimata, J.T., Anderson, P.L., Nehete, P.N., Arduino, R.C., Ferrari, M., Sastry, K.J., Grattoni, A.
Advanced Therapeutics, 2020, 4(3), 2000163
|
|
Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantationPaez-Mayorga, J., Capuani, S., Hernandez, N., Farina, M., Chua, C. Y. X., Blanchard, R., Sizovs, A., Liu, H.C., Fraga, D.W., Niles, J.A., Salazar, H.F., Corradetti, B., Sikora, A.G., Kloc, M., Li, X.C., Gaber, A.O., Nichols, J.E. and Grattoni, A
Biomaterials, 2020, 257, 120232.
|
|
Viral load Reduction in SHIV-Positive Nonhuman Primates via Long-Acting Subcutaneous Tenofovir Alafenamide Fumarate Release from a Nanofluidic ImplantPons-Faudoa, F. P.; Di Trani, N.; Sizovs, A.; Shelton, K. A.; Momin, Z.; Bushman, L. R.; Xu, J.; Lewis, D. E.; Demaria, S.; Hawkins, T.; Rooney, J. F.; Marzinke, M. A.; Kimata, J. T.; Anderson, P. L.; Nehete, P. N.; Arduino, R. C.; Sastry, K. J.; Grattoni, A.
Pharmaceutics 2020, 12 (10), 981.
|
|
Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and antiPDL1Liu, H.C., Viswanath, D.I., Pesaresi, F., Xu, Y., Zhang, L., Di Trani, N., Paez-Mayorga, J., Hernandez, N., Wang, Y., Erm, D.R. and Ho, J.,
International Journal of Radiation Oncology Biology Physics 2020
|
|
Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes ElutionDi Trani, N.; Silvestri, A.; Wang, Y.; Demarchi, D.; Liu, X.; Grattoni, A.
Pharmaceutics 2020, 12, 679.
|
|
Intratumoral nanofluidic system for enhancing tumor biodistribution of agonist CD40 antibodyChua C. Y. X., Ho J., Susnjar A., Lolli G., Di Trani N., Pesaresi F., Sizovs A., Zhang M., Nance E., and Grattoni A.
Advanced Therapeutics, 2020, 2000055.
|
|
Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of FormoterolBallerini A., Chua C. Y. X., Rhudy J., A. Susnjar, Di Trani N., Jain P. R., Laue g., Lubicka D., Shirazi‐Fard Y., Ferrari M., Stodieck L. S., Cadena S. M. and Grattoni A.
Advanced Therapeutics, 3(7), 2000014.
|
|
Electrostatically Gated Nanofluidic Membrane for Ultra-Low Power Controlled Drug DeliveryDi Trani N., Silvestri A., Sizovs A., Wang Y., Erm D. R., Demarchi D., Liu X. and Grattoni A.
Lab on a Chip, 2020, 20, 1562–1576
|
|
Finite-Size Charged Species Diffusion and pH Change in NanochannelsDi Trani, N., Pimpinelli, A. & Grattoni, A.
ACS Applied Materials & Interfaces 2020, 12, 12246-12255
|
2019
|
2-Hydroxypropyl-β-Cyclodextrin-Enhanced Pharmacokinetics of Cabotegravir from a Nanofluidic Implant for HIV Pre-Exposure ProphylaxisPons-Faudoa, F. P.; Sizovs, A.; Di Trani, N.; Paez-Mayorga, J.; Bruno, G.; Rhudy, J.; Manohar, M.; Gwenden, K.; Martini, C.; Chua, C. Y. X.; Varchi, G.; Marzinke, M. A.; Grattoni, A.
Journal of Controlled Release 2019, 306, 89–96.
|
|
Remotely Controlled Nanofluidic Implantable Platform for Tunable Drug DeliveryDi Trani, N.; Silvestri, A.; Bruno, G.; Geninatti, T.; Chua, C. Y. X.; Gilbert, A.; Rizzo, G.; Filgueira, C. S.; Demarchi, D.; Grattoni, A.
Lab on a Chip 2019, 19 (13), 2192–2204.
|
|
Nanofluidic microsystem for sustained intraocular delivery of therapeuticsDi Trani N, Jain P, Bruno G, Chua CYX., Ho JS, Hood LR, Smith ZW, Ballerini A, Filgueira CS, Grattoni A.
Nanomedicine: Nanotechnology, Biology and Medicine. 2019 Feb 1;16:1–9.
|
2018
|
Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxisChua CY, Jain P, Ballerini A, Bruno G, Hood RL, Gupte M, Gao S, Di Trani N, Susnjar A, Shelton K, Bushman LR. Folci M., Filgueira CS, Marzinke M A, Anderson PL, Hu M, Nehete P, Arduino RC, Sastry JK, Grattoni A
Journal of Controlled Release. 2018 Sep 28;286:315-25.
|
|
Gas Flow at the Ultra-nanoscale: Universal Predictive Model and Validation in Nanochannels of Ångstrom-Level ResolutionScorrano G, Bruno G, Di Trani N, Ferrari M, Pimpinelli A, Grattoni A.
ACS Applied Materials & Interfaces. 2018 Sep 5;10(38):32233-8
|
|
Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscaleBruno G, Di Trani N, Hood R, Zabre E, Filgueira C, Canavese G, Jain P, Smith Z, Demarchi D, Hosali S, Pimpinelli A, Ferrari M, Grattoni A.
Nature Communications, 2018 Apr 27;9(1):1682.
|
|
Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancerChua, C. Y. X.; Jain, P.; Susnjar, A.; Rhudy, J.; Folci, M.; Ballerini, A.; Gilbert, A.; Singh, S.; Bruno, G.; Filgueira, C. S.
Journal of Controlled Release 2018, 285, 23-34
|
|
Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cellsFarina, M.; Chua, C. Y. X.; Ballerini, A.; Thekkedath, U.; Alexander, J. F.; Rhudy, J. R.; Torchio, G.; Fraga, D.; Pathak, R. R.; Villanueva, M.
Biomaterials 2018, 177, 125-138
|
|
Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyondFarina, M.; Alexander, J. F.; Thekkedath, U.; Ferrari, M.; Grattoni, A.
Advanced Drug Delivery Reviews 2019, 139, 92-115
|
Patents
2020 U.S. Provisional Pat. Ser. No. 63/043,439. “Transcutaneously refillable cell confinement platform with local trophic factor delivery.” Grattoni, A., Paez-Mayorga, J. & Capuani, S.
2020 US Provisional Patent Application 62,961,294, “Formulations for stabilizing phosphonamidite esters in long-term drug delivery systems.” Grattoni A., Sizovs A., Pons F.P.
2020 US Provisional Patent Application 62/943,993, “Methods for loading drug-delivery implants with solid materials.” Grattoni A., Sizovs A.
2020 US Provisional Patent Application 62/961,437, “Gated nanofluidic valve for active and passive electrosteric control of molecular transport, and methods of fabrication.” Grattoni A., Liu, X., Ferrari, M.
2017 US Patent Application 62/573,339, “Delivery Devices.” Farina M., Ballerini A., Gaber A.O., Grattoni, A.
2015 US Provisional Patent Application No. 62/161,986, Mechanism to remotely and externally cease drug delivery in vivo.” Grattoni A., Farina M., Hood, RL.
2015 US Provisional Patent Application No. 61/861,070. “Nanochanneled Device with Electrodes and Related Methods.” Fine D., Grattoni A., Hussain F., Ferrari M., Liu X., Goodall R., Hosali S.
2014 US Provisional Patent Application No. 62/161,986, “Implantable Nanochannel Drug (e.g., chemotherapy, antobodies gene therapy in viral particles) Delivery Combined with Fiducial Markers and Radioactive Seeds for Sustained, Multi-modal Cancer Treatment.” Grattoni A., Palapattu G., Butler BE.
2014 US Patent Application No. US 13/698,926, “Nanochanneled Device and Related Methods.” Grattoni A., Mann A., Hosali S., Goodall R., Hudson L.
2014 US Patent No. 8,632,510, “Nanochanneled Device and Related Methods.” Mauro Ferrari, Xuewu Liu, Grattoni A., Goodall R., Hudson L. (also pending in Canada, China, Europe).
2013 US Patent Application No. PCT/US2013/022987. “Sustained drug delivery from solid implants with nanochannel membranes.” Grattoni A., Palapattu G., Khera M.
2013 US Patent No. 8,480,637, “Nanochanneled Device and Related Methods.” Mauro Ferrari, Xuewu Liu, Grattoni A., Goodall R., Hudson L. (also pending in Canada, China, Europe).
2009 US Patent Application No. 13/659,064, “Device and Method for Sustained Release of Therapeutic Agent.” Grattoni A., De Rosa E., Goodall R., Hudson L., Crowley M. (also International Patent Application No. PCT/US2012/061536).
2007 US Patent Application No. PCT/US2009/041957 “Quality control method and micro/nano-channeled devices.” Grattoni A., Ferrari M., Liu X.
2006 IT Patent No. TO2007A000177. “Dispositivo perfezionato di misura della pressione osmotica e relative procedimento di misura.” Canavese G., Grattoni A.
2006 IT Patent No. T02006A000508. “Osmotic pressure measurement device and measurement method.” Grattoni A., Canavese G.